IBS Tales Home > Treatment Reviews > IBS Medications > Duspatalin


Overall rating 4/5 based on 6 reviews

Duspatalin (mebeverine hydrochloride) is an anti-spasmodic medication, which means it acts on the muscles in the gut and causes them to relax. It contains the same main ingredient as the UK drug Colofac. Duspatalin is designed to treat intestinal spasms, cramps, bloating and wind, as well as the diarrhea or constipation which accompany these symptoms. It comes in tablet form and is swallowed with water.

This medication comes in two strengths. You may be given the standard 135mg pills or a 200mg long-acting version which works over a more prolonged period and is known in some countries as Duspatalin Retard 200mg.

Duspatalin side effects

The most common side effects of Duspatalin are angioedema (swelling beneath the skin), hypersensitivity or allergic reactions, a skin rash and urticaria (hives).


Review by Amanda

I was given Duspatalin as a remedy for acute stomach cramps and I have been scratching my skin ever since. My stomach pain has gone but I have come up in loads of hives. It is very irritating, I simply can't stop scratching! I'm too worried to stop taking the tablets in case I develop the debilitating stomach cramps again.

Review by Azhar

I have suffered from IBS for many years and it interferes with my life physically and socially. I took Duspatalin Retard 200mg for a few weeks with an obvious improvement, but when I stopped taking this medicine the symptoms returned. Now I am wondering for how long I can take this drug and if I take it for a long time whether there are any undesirable effects or some sort of dependency.

Review by Ram

I have been diagnosed with IBS and it was recommended that I take Duspatalin. I have commenced this treatment with Duspatalin Retard (200mg) and I have shown remarkable improvement. The dosage taken is one tablet twice a day before meals.

Review by Gabby

I just wanted to let you know that I just started taking Duspatalin 135mg and Librax three times a day, 30 minutes before I eat. I started to feel better from the next day. I also take probiotics two times a day after a meal. I recommend this medicine because it made me feel so much better. I thought I was going to explode before I started to take the medicine.

Review by Sara

I've been taking Duspatalin for about six weeks now and I am extremely happy with it. I have zero side effects, and can eat almost normally for the first time in 10 years. Even foods that usually gave me terrible diarrhea I can now eat in moderation (eg: chocolate mousse, croissants or avocado - one portion a day is no problem). And if I overdo it, I may have diarrhea, but with much less cramping. My quality of life has improved tremendously.

Review by Andrè

I have been suffering from IBS for many years. I had all sorts of tests looking for other illnesses but it all comes back to work stress and IBS. Recently I was hospitalized with suspected appendicitis, but it proved to be a false alarm. They did further tests and ruled out bacterial infection or any obvious virus.

Several weeks later I have improved from the acute phase, but it seems that it really is the IBS again, but much stronger than ever before. And I feel stupid for having been to hospital and wasting people's time, including my own. I guess my health insurer may not be too amused either! I was prescribed Librax, which made me a bit too sleepy in the day, but was very nice for helping my insomnia! So the doctor changed to Duspatalin which apparently is similar/the same as Colofac in the UK.

Duspatalin is not as effective as Librax, but it has definitely reduced the pains and cramps very significantly, with no drowsiness. It allows me to lead a fairly normal life, including being able to socialize and drink small amounts of alcohol with meals, unlike Librax which shouldn't be mixed with alcohol.

Now I need to work out which foods, if any, are really triggering the IBS. My doctor recommends keeping off fibrous vegetables, but then if I do that I get constipated. Otherwise I have also tried Metamucil (psyllium husks) but I find it pretty tough to stomach for some reason, so the search goes on.

Do you suffer from IBS? Have you tried Duspatalin? Please contact Sophie to send in your review.